Devices for spray applications complete the large variety of dispersing systems. SPRAYER and INHALER for pump sprays, propellant gas sprays, and inhalers, open completely new applications for the characterisation of pharmaceutical sprays and inhalation drugs. Applications with extremely low optical concentrations and a duration of only milliseconds are now accessible due to improvements in the sensitivity of the sensor and the availability of powerful trigger algorithms.

SPRAYER

SPRAYER with metered dosed inhaler(MDI)

Rear view of the SPRAYER with propellant gas spray and electronic trajectory actuator inserted in the measuring zone of the laser diffraction sensor HELOS. The cover is removed for clarity.

The SPRAYER is a versatile adapter of pump sprays or propellant gas sprays to the HELOS sensor for the measurement of particle and droplet size distributions.

As the results are usually depending on a variety of parameters, e.g. the force or the time behaviour driving the spraying process, the distance to the measuring volume, the orientation of the spraying direction with respect to the direction of the gravity of earth, etc., the spraying process has to be performed under controlled conditions:

  • The actuating piston can be controlled by software in terms of acceleration, velocity, stroke length or at definable constant force. The complete actuation process is controlled and monitored by software.
  • The distance of spray outlet to the measuring volume can be varied under software control.
  • The direction of the spray can be varied by using ROTOR/M as an option.

The measurement can be performed by the WINDOX software with integrating over the complete process, separating it in thee time intervals (FDA compliant) or time resolved with definable resolution.

INHALER

INHALER with discus installed

Side view of the INHALER mounted to the measuring zone of a VARIO/KF showing a discus style inhaler (device to be tested), the discus holder, the 90° elbow, the pre-separator, the central stage with control panel, the Venturi meter the fine particle collector and the wash bottle.

The INHALER is a versatile adapter for the investigation and the development of all kinds of inhalers, propellant gas sprays or pump sprays.

The central stage with the measuring chamber and the vacuum control unit can be adapted to the various needs by a flexible tool kit comprising

  • a discus adapter
  • elongation front cylinder
  • 90° elbow
  • pre-separator
  • Venturi meter
  • fine particle collector or wash bottle
  • vacuum pump

Troughput and inclination angle (for nebulizers) are controlled by software. Ambient temperature, humidity, air pressure etc. are recorded.

As with the SPRAYER the WINDOX software allows for integrated or time resolved measurements.

Nebulizers, Sprays
and Inhalers

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Symbol: Sympatec Cactussymbol: wet dispersion for suspensions or emulsions